2025 College Football Week 5 features Oregon Vs Penn St., LSU Vs Ole Miss, and Alabama Vs Georgia.
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Week 5
Friday, September 26th, 2025:
Forida St. Vs Virginia
Vegas: Forida St. -6.5
College Football Game Picker: Forida St. by 15.30
Florida St. has been one of the surprise teams this year after knocking off Alabama in the opener and cruising through its schedule so far. Florida St. has been way undervalued by Vegas with a +23 against the spread average. Florida St. has played a much more difficult schedule than Virginia. The 1st ranked rushing offense of Florida St should be able to move the ball on the 33rd ranked rush defense of Virginia. Virginia will be sky high for this one, but it won’t matter. Look for 6th ranked Florida St. to cover the spread against 42nd ranked Virginia.
Saturday, September 27th, 2025:
USC Vs Illinois
Vegas: USC -6.5
College Football Game Picker: USC by 15.60
Illinois got absolutely boat raced by Indiana this past weekend in what was supposed to be a competitive game. USC, meanwhile, has been taking care of business while running an extremely productive offense. USC will be able to move the ball on Illinois much the way Indiana did with its 10th ranked rushing offense and 8th ranked pass offense. The normally efficient rush offense of Illinois has been terrible this year ranking 112th. USC has been undervalued by Vegas with a +6 against the spread average. Look for 14th ranked USC to cover the spread in this one against 30th ranked Illinois.
Saturday, September 27th, 2025:
Ga. Southern Vs James Madison
Vegas: James Madison -15.5
College Football Game Picker: James Madison by 19.81
The Ga. Southern defense has been horrible thus far ranking 135th in rush defense and 108th in pass defense. James Madison will have a huge mismatch with its 39th ranked rushing offense going against the woeful rush defense of Ga Southern. James Madison has been extremely stout on defense ranking 4th in pass defense and 54th in rush defense. James Madison had been undervalued by Vegas with a +7 against the spread average. Look for James Madison to cover the spread at home against Ga. Southern.
Saturday, September 27th, 2025:
Indiana Vs Iowa
Vegas: Indiana -6.5
College Football Game Picker: Indiana by 15.44
Indiana absolutely demolished Illinois this past weekend while Iowa struggled to get past Rutgers late. Indiana should be able to stack the box against the one-dimensional running offense of Iowa. Iowa will not be able to pass the ball on Indiana with its 113th ranked passing offense. Indiana’s 4th ranked rushing offense and 51st ranked passing offense will be able to score points on the better than average defense of Iowa much like Rutgers did. Look for 3rd ranked Indiana to cover the spread in this one against 34th ranked Iowa.
Saturday, September 27th, 2025:
Ohio St. Vs Washington
Vegas: Ohio St. -8.5
College Football Game Picker: Ohio St. by 10.60
If you look at the strength of schedule for these two teams, Washington is ranked 105th and Ohio St. is ranked 5th. Ohio St. will be able to shut down Washington just like it did Texas in the opener. Washington has great stats against much weaker opponents and will struggle to stop the Ohio St high flying offense that will likely concentrate on moving the ball through the air with its talented wide receivers. Look for 1st ranked Ohio St. to cover the spread in this one against 26th ranked Washington.
Saturday, September 27th, 2025:
BYU Vs Colorado
Vegas: BYU -6.5
College Football Game Picker: BYU by 14.63
BYU has been tremendous on defense this year ranking 11th in rushing defense and 52nd in pass defense. BYU has been undervalued by Vegas with a +14 against the spread average while Colorado is -2 against the spread average. BYU should be able to move the ball on the ground with its 51st ranked rushing offense going against the 102nd ranked rush defense of Colorado. The strength of schedule has been about the same for these two teams with BYU having much better results. Look for BYU to cover the spread in this one.







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