2025 College Football Week 5 will feature Oregon Vs Penn St, LSU Vs Ole Miss, and Alabama Vs Georgia.
We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well!
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread.
The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Thursday, September 25th, 2025:
Army Vs E. Carolina
Vegas: E. Carolina -3.5
College Football Game Picker: E. Carolina by 9.21
Friday, September 26th, 2025:
Forida St. Vs Virginia
This game is a Premium Pick. See Premium Picks for the lock.
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TCU Vs Arizona St.
Vegas: Arizona St. -2.5
College Football Game Picker: TCU by 3.89
Houston Vs Oregon St.
Vegas: Houston -12.5
College Football Game Picker: Houston by 19.19
Saturday, September 27th, 2025:
Bowling Green Vs Ohio
Vegas: Ohio -10.5
College Football Game Picker: Ohio by 9.03
Notre Dame Vs Arkansas
Vegas: Notre Dame -5.5
College Football Game Picker: Notre Dame by 3.58
Louisville Vs Pittsburgh
Vegas: Louisville -4.5
College Football Game Picker: Louisville by 3.32
Duke Vs Syracuse
Vegas: Duke -5.5
College Football Game Picker: Syracuse by 11.22
Georgia Tech Vs Wake Forest
Vegas: Georgia Tech -13.5
College Football Game Picker: Georgia Tech by 22.29
Rutgers Vs Minnesota
Vegas: Minnesota -4.5
College Football Game Picker: Minnesota by 3.59
Cincinnati Vs Kansas
Vegas: Kansas -5.5
College Football Game Picker: Kansas by 2.84
S. Alabama Vs N. Texas
Vegas: N. Texas -12.5
College Football Game Picker: N. Texas by 16.85
C. Florida Vs Kansas St.
Vegas: Kansas St. -6.5
College Football Game Picker: C. Florida by 6.85
USC Vs Illinois
This game is a Premium Pick. See Premium Picks for the lock.
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Utah St. Vs Vanderbilt
Vegas: Vanderbilt -22.5
College Football Game Picker: Vanderbilt by 28.89
E. Michigan Vs C. Michigan
Vegas: C. Michigan -6.5
College Football Game Picker: C. Michigan by 0.13
Ga. Southern Vs James Madison
This game is a Premium Pick. See Premium Picks for the lock.
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Arkansas St. Vs La Monroe
Vegas: La Monroe -1.5
College Football Game Picker: Arkansas St. by 1.35
Akron Vs Toledo
Vegas: Toledo -21.5
College Football Game Picker: Toledo by 31.68
Utah Vs W. Virginia
Vegas: Utah -12.5
College Football Game Picker: Utah by 16.90
San Diego St. Vs N. Illinois
Vegas: San Diego St. -2.5
College Football Game Picker: San Diego St. by 7.49
California Vs Boston College
Vegas: Boston College -6.5
College Football Game Picker: Boston College by 10.63
UConn Vs Buffalo
Vegas: UConn -2.5
College Football Game Picker: UConn by 8.87
Indiana Vs Iowa
This game is a Premium Pick. See Premium Picks for the lock.
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UCLA Vs Northwestern
Vegas: Northwestern -6.5
College Football Game Picker: Northwestern by 11.39
Rice Vs Navy
Vegas: Navy -14.5
College Football Game Picker: Navy by 16.62
Baylor Vs Oklahoma St.
Vegas: Baylor -19.5
College Football Game Picker: Baylor by 25.88
LSU Vs Ole Miss
Vegas: Ole Miss -1.5
College Football Game Picker: Ole Miss by 7.99
Auburn Vs Texas A&M
Vegas: Texas A&M -6.5
College Football Game Picker: Texas A&M by 5.25
Ohio St. Vs Washington
This game is a Premium Pick. See Premium Picks for the lock.
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Hawaii Vs Air Force
Vegas: Air Force -6.5
College Football Game Picker: Air Force by 1.94
New Mexico St. Vs New Mexico
Vegas: New Mexico -13.5
College Football Game Picker: New Mexico by 20.06
Tulane Vs Tulsa
Vegas: Tulane -14.5
College Football Game Picker: Tulane by 13.45
Mississippi St. Vs Tennessee
Vegas: Tennessee -8.5
College Football Game Picker: Tennessee by 6.95
Liberty Vs Old Dominion
Vegas: Old Dominion -15.5
College Football Game Picker: Old Dominion by 20.91
Middle Tennessee Vs Kennesaw St.
Vegas: Kennesaw St. -7
College Football Game Picker: Kennesaw St. by 8.52
Memphis Vs Florida Atl.
Vegas: Memphis -13.5
College Football Game Picker: Memphis by 20.69
Virginia Tech Vs NC State
Vegas: NC State -10.5
College Football Game Picker: NC State by 14.40
Jacksonville St. Vs Southern Miss
Vegas: Southern Miss -4.5
College Football Game Picker: Southern Miss by 0.17
Arizona Vs Iowa St.
Vegas: Iowa St. -6.5
College Football Game Picker: Iowa St. by 1.12
W. Kentucky Vs Missouri St.
Vegas: W. Kentucky -4.5
College Football Game Picker: W. Kentucky by 10.64
Appalachian St. Vs Boise St.
Vegas: Boise St. -17.5
College Football Game Picker: Boise St. by 14.40
San Jose St. Vs Stanford
Vegas: Stanford -1.5
College Football Game Picker: Stanford by 11.53
UMass Vs Missouri
Vegas: Missouri -43.5
College Football Game Picker: Missouri by 58.54
Washington St. Vs Colorado St.
Vegas: Colorado St. -4.5
College Football Game Picker: Colorado St. by 6.30
Oregon Vs Penn St.
Vegas: Penn St. -3.5
College Football Game Picker: Oregon by 7.89
Alabama Vs Georgia
Vegas: Georgia -3.5
College Football Game Picker: Alabama by 6.12
Kentucky Vs S. Carolina
Vegas: S. Carolina -6.5
College Football Game Picker: S. Carolina by 1.84
Marshall Vs Louisiana
Vegas: Louisiana -2.5
College Football Game Picker: Marshall by 2.71
La Tech Vs UTEP
Vegas: La Tech -4
College Football Game Picker: La Tech by 9.07
BYU Vs Colorado
This game is a Premium Pick. See Premium Picks for the lock.
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