2025 College Football Week 10 will feature Cincinnati Vs Utah, Vanderbilt Vs Texas, and Oklahoma Vs Tennessee.
We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well!
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread.
The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Tuesday, October 28th, 2025:
UTEP Vs Kennesaw St.
Vegas: Kennesaw St. -9.5
College Football Game Picker: Kennesaw St. by 10.86
James Madison Vs Texas St.
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
Wednesday, October 29th, 2025:
Jacksonville St. Vs Middle Tennessee
Vegas: Jacksonville St. -5.5
College Football Game Picker: Jacksonville St. by 5.61
Florida Intl. Vs Missouri St.
Vegas: Missouri St. -3.5
College Football Game Picker: Missouri St. by 4.80
Thursday, October 30th, 2025:
Marshall Vs Coastal Carolina
Vegas: Marshall -3.5
College Football Game Picker: Marshall by 11.17
Tulane Vs UTSA
Vegas: Tulane -3.5
College Football Game Picker: Tulane by 7.06
Friday, October 31st, 2025:
Memphis Vs Rice
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
N. Carolina Vs Syracuse
Vegas: Syracuse -1.5
College Football Game Picker: Syracuse by 10.22
Sam Houston Vs La Tech
Vegas: La Tech -16.5
College Football Game Picker: La Tech by 21.88
Saturday, November 1st, 2025:
W. Virginia Vs Houston
Vegas: Houston -13.5
College Football Game Picker: Houston by 15.94
C. Florida Vs Baylor
Vegas: Baylor -4.5
College Football Game Picker: C. Florida by 5.13
Penn St. Vs Ohio St.
Vegas: Ohio St. -20.5
College Football Game Picker: Ohio St. by 21.62
Rutgers Vs Illinois
Vegas: Illinois -12.5
College Football Game Picker: Illinois by 10.94
Army Vs Air Force
Vegas: Air Force -1.5
College Football Game Picker: Army by 7.42
UAB Vs UConn
Vegas: UConn -11.5
College Football Game Picker: UConn by 14.75
Navy Vs N. Texas
Vegas: N. Texas -6.5
College Football Game Picker: N. Texas by 14.59
Vanderbilt Vs Texas
Vegas: Texas -1.5
College Football Game Picker: Texas by 4.47
Duke Vs Clemson
Vegas: Clemson -3.5
College Football Game Picker: Clemson by 6.95
Buffalo Vs Bowling Green
Vegas: Bowling Green -1.5
College Football Game Picker: Bowling Green by 4.86
Miami FL Vs SMU
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
Arizona St. Vs Iowa St.
Vegas: Iowa St. -5.5
College Football Game Picker: Iowa St. by 3.47
E. Carolina Vs Temple
Vegas: E. Carolina -4.5
College Football Game Picker: E. Carolina by 9.39
New Mexico Vs UNLV
Vegas: UNLV -4.5
College Football Game Picker: UNLV by 2.20
Louisville Vs Virginia Tech
Vegas: Louisville -10.5
College Football Game Picker: Louisville by 16.92
New Mexico St. Vs W. Kentucky
Vegas: W. Kentucky -8.5
College Football Game Picker: W. Kentucky by 10.31
Delaware Vs Liberty
Vegas: Liberty -3.5
College Football Game Picker: Liberty by 4.34
Louisiana Vs S. Alabama
Vegas: S. Alabama -4.5
College Football Game Picker: S. Alabama by 5.49
Old Dominion Vs La Monroe
Vegas: Old Dominion -14.5
College Football Game Picker: Old Dominion by 23.01
Indiana Vs Maryland
Vegas: Indiana -21.5
College Football Game Picker: Indiana by 27.13
Texas Tech Vs Kansas St.
Vegas: Texas Tech -7.5
College Football Game Picker: Texas Tech by 15.36
Notre Dame Vs Boston College
Vegas: Notre Dame -28.5
College Football Game Picker: Notre Dame by 35.11
Michigan St. Vs Minnesota
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
Fresno St. Vs Boise St.
Vegas: Boise St. -17.5
College Football Game Picker: Boise St. by 19.04
Pittsburgh Vs Stanford
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
Georgia Vs Florida
Vegas: Georgia -7.5
College Football Game Picker: Georgia by 12.38
Virginia Vs California
Vegas: Virginia -3.5
College Football Game Picker: Virginia by 11.30
C. Michigan Vs W. Michigan
Vegas: W. Michigan -4.5
College Football Game Picker: W. Michigan by 10.41
Mississippi St. Vs Arkansas
Vegas: Arkansas -4.5
College Football Game Picker: Arkansas by 1.47
Oklahoma St. Vs Kansas
Vegas: Kansas -24.5
College Football Game Picker: Kansas by 24.22
S. Carolina Vs Ole Miss
Vegas: Ole Miss -12.5
College Football Game Picker: Ole Miss by 15.43
Arizona Vs Colorado
Vegas: Arizona -4.5
College Football Game Picker: Arizona by 7.57
Wyoming Vs San Diego St.
Vegas: San Diego St. -10.5
College Football Game Picker: San Diego St. by 13.36
Purdue Vs Michigan
Vegas: Michigan -21.5
College Football Game Picker: Michigan by 25.34
Kentucky Vs Auburn
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 10
Wake Forest Vs Florida St.
Vegas: Florida St. -8.5
College Football Game Picker: Florida St. by 16.01
Southern Cal Vs Nebraska
Vegas: Southern Cal -6.5
College Football Game Picker: Southern Cal by 10.26
Washington St. Vs Oregon St.
Vegas: Washington St. -3.5
College Football Game Picker: Washington St. by 10.09
Georgia Tech Vs NC State
Vegas: Georgia Tech -5.5
College Football Game Picker: Georgia Tech by 9.22
Oklahoma Vs Tennessee
Vegas: Tennessee -3.5
College Football Game Picker: Oklahoma by 1.39
Arkansas St. Vs Troy
Vegas: Troy -7.5
College Football Game Picker: Troy by 8.86
Cincinnati Vs Utah
Vegas: Utah -7.5
College Football Game Picker: Utah by 16.33
Hawaii Vs San Jose St.
Vegas: San Jose St. -2.5
College Football Game Picker: Hawaii by 5.02
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