2025 College Football Week 13 will feature Louisville Vs SMU, USC Vs Oregon, and Missouri Vs Oklahoma.
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Week 13
Friday, November 21st, 2025:
Florida St. Vs NC State
Vegas: Florida St. -3.5
College Football Game Picker: Florida St. by 13.09
Florida St. put a whooping on Virginia Tech this past weekend and seems to be gaining back its swagger. Florida St. once again has a great matchup in this game. Florida St.’s 37th ranked pass offense should have a big advantage on the 136th ranked pass defense of NC State. Florida St. should also be able to move the ball on the ground as well with its 16th ranked rush offense. NC State will have to rely on its passing game as the 23rd ranked rush defense of Florida St. will be able to shut down their running game. Look for 22nd ranked Florida St. to cover the spread in this one against 52nd ranked NC State.
Saturday, November 22nd, 2025:
Tulane Vs Temple
Vegas: Tulane -6.5
College Football Game Picker: Tulane by 9.44
Tulane is still fighting for an outside chance at a playoff position and will have a good matchup in this game. The 43rd ranked rush offense of Tulane should be able to run efficiently against the 125th ranked rush defense of Temple. The main weakness of Tulane this year has been their pass defense ranking 113th. Temple won’t be able to take advantage with its 96th ranked pass offense. Tulane has played a much tougher schedule and has much better statistics. Look for 62nd ranked Tulane to use its mismatches to cover the spread in this one against 96th ranked Temple.
Saturday, November 22nd, 2025:
Colorado St. Vs Boise St.
Vegas: Boise St. -16.5
College Football Game Picker: Boise St. by 26.53
Boise St. has had two bad games in a row where they did not match up well against its opponents which explains this line. This week Boise St. can just run the ball at will with its 46th ranked rushing offense going against the 127th ranked rush defense of Colorado St. Boise St. will be able to stack the box against Colorado St. as Colorado St. will not be able to get any passing going with its 105th ranked passing offense going against the 9th ranked pass defense of Boise State. Look for 53rd ranked Boise St. to rebound with a resounding win in this game against 115th ranked Colorado St.
Saturday, November 22nd, 2025:
E. Carolina Vs UTSA
Vegas: E. Carolina -2.5
College Football Game Picker: E. Carolina by 12.76
The difference in this game will be E. Carolina’s ability to move the ball efficiently through the air and on the ground with its 28th ranked rush offense and 24th ranked pass offense going against the 99th ranked rush defense and 92nd ranked pass defense of UTSA. UTSA will struggle to get its running game going against the 27th ranked rush defense of E. Carolina. The pass offense of UTSA will be kept in check as well. E. Carolina has been way undervalued by Vegas this year with a +10 against the spread average. Look for E. Carolina to cover the spread in this one.
Saturday, November 22nd, 2025:
Minnesota Vs Northwestern
Vegas: Over/Under 41.5
College Football Game Picker: Take the Under
This is a game where the defenses will dominate the offenses. Minnesota has no running game ranking 129th in running offense. Minnesota’s passing game is not much better and will have to go against the 25th ranked pass defense of Northwestern. On the other side of the ball, Northwestern has no passing game ranking 121st. Northwestern’s 45th ranked rushing offense will have to go against the 29th ranked Minnesota defense which will be stacking the box. Look for this to be a low scoring game. Take the under in this one.
Saturday, November 22nd, 2025:
Old Dominion Vs Ga Southern
Vegas: Old Dominion -9.5
College Football Game Picker: Old Dominion by 19.61
Old Dominion had a week off to prepare for this game while Ga Southern has struggled the past two weeks to get past a couple of really bad teams in Coastal Carolina and Appalachian St. Old Dominion has been rolling in its last two games winning in dominating fashion against Troy and La Monroe. Old Dominion will have a massive advantage with its 14th ranked rushing offense going against the 136th ranked rushing defense of Georgia Southern. Ga. Southern will not be able to get much going on offense against the stingy Old Dominion defense. Look for 63rd ranked Old Dominion to cover the spread in this one against 106th ranked Ga Southern.
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