2025 College Football Week 12 will feature Notre Dame Vs Pittsburgh, Texas Vs Georgia, Iowa Vs USC, and Oklahoma Vs Alabama.
We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well!
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread.
The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Choose a matchup above to view the head-to-head comparison for each game.
Tuesday, November 11th, 2025:
Kent St. Vs Akron
Vegas: Akron -6.5
College Football Game Picker: Akron by 6.40
Ohio Vs W. Michigan
Vegas: W. Michigan -1.5
College Football Game Picker: Ohio by 0.67
Wednesday, November 12th, 2025:
N. Illinois Vs UMass
Vegas: N. Illinois -11.5
College Football Game Picker: N. Illinois by 15.77
Toledo Vs Miami OH
Vegas: Toledo -3.5
College Football Game Picker: Toledo by 11.12
Buffalo Vs C. Michigan
Vegas: C. Michigan -2.5
College Football Game Picker: C. Michigan by 1.45
Thursday, November 13th, 2025:
Troy Vs Old Dominion
Vegas: Old Dominion -10.5
College Football Game Picker: Old Dominion by 13.05
Friday, November 14th, 2025:
Clemson Vs Louisville
Vegas: Louisville -3.5
College Football Game Picker: Louisville by 0.30
Minnesota Vs Oregon
Vegas: Oregon -23.5
College Football Game Picker: Oregon by 27.06
Saturday, November 15th, 2025:
UTSA Vs Charlotte
Vegas: UTSA -17.5
College Football Game Picker: UTSA by 24.74
Michigan Vs Northwestern
Vegas: Michigan -10.5
College Football Game Picker: Michigan by 13.00
E. Michigan Vs Ball St.
Vegas: E. Michigan -2.5
College Football Game Picker: E. Michigan by 5.82
Notre Dame Vs Pittsburgh
Vegas: Notre Dame -12.5
College Football Game Picker: Notre Dame by 11.53
Air Force Vs UConn
Vegas: UConn -7.5
College Football Game Picker: UConn by 9.96
Arizona Vs Cincinnati
Vegas: Cincinnati -6.5
College Football Game Picker: Cincinnati by 0.02
S. Carolina Vs Texas A&M
Vegas: Texas A&M -18.5
College Football Game Picker: Texas A&M by 20.25
S. Florida Vs Navy
This game is a Premium Pick. See Premium Picks for the lock.
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Wisconsin Vs Indiana
Vegas: Indiana -30.5
College Football Game Picker: Indiana by 30.74
Kansas St. Vs Oklahoma St.
Vegas: Kansas St. -19.5
College Football Game Picker: Kansas St. by 23.36
Arkansas Vs LSU
Vegas: LSU -5.5
College Football Game Picker: LSU by 8.98
W. Virginia Vs Arizona St.
This game is a Premium Pick. See Premium Picks for the lock.
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Oregon St. Vs Tulsa
Vegas: Oregon St. -1.5
College Football Game Picker: Oregon St. by 7.32
N. Texas Vs UAB
Vegas: N. Texas -17.5
College Football Game Picker: N. Texas by 24.00
Marshall Vs Georgia St.
Vegas: Marshall -7.5
College Football Game Picker: Marshall by 12.84
Colorado St. Vs New Mexico
Vegas: New Mexico -14.5
College Football Game Picker: New Mexico by 15.77
UTEP Vs Missouri St.
Vegas: Missouri St. -4.5
College Football Game Picker: Missouri St. by 2.91
Iowa Vs USC
Vegas: USC -6.5
College Football Game Picker: USC by 5.15
Penn St. Vs Michigan St.
Vegas: Penn St. -6.5
College Football Game Picker: Penn St. by 11.96
Oklahoma Vs Alabama
Vegas: Alabama -6.5
College Football Game Picker: Alabama by 9.78
NC State Vs Miami FL
Vegas: Miami FL -14.5
College Football Game Picker: Miami FL by 18.81
Texas St. Vs Southern Miss
Vegas: Southern Miss -6.5
College Football Game Picker: Southern Miss by 3.94
S. Alabama Vs La Monroe
Vegas: S. Alabama -3.5
College Football Game Picker: S. Alabama by 10.53
San Jose St. Vs Nevada
Vegas: San Jose St. -8.5
College Football Game Picker: San Jose St. by 13.19
Virginia Vs Duke
Vegas: Duke -6.5
College Football Game Picker: Duke by 0.24
C. Florida Vs Texas Tech
Vegas: Texas Tech -23.5
College Football Game Picker: Texas Tech by 23.37
Appalachian St. Vs James Madison
Vegas: James Madison -19.5
College Football Game Picker: James Madison by 25.76
Maryland Vs Illinois
Vegas: Illinois -14.5
College Football Game Picker: Illinois by 14.72
Georgia Tech Vs Boston College
This game is a Premium Pick. See Premium Picks for the lock.
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Middle Tenn. Vs W. Kentucky
Vegas: W. Kentucky -13.5
College Football Game Picker: W. Kentucky by 13.93
Memphis Vs E. Carolina
Vegas: E. Carolina -2.5
College Football Game Picker: E. Carolina by 4.47
Florida Atl. Vs Tulane
Vegas: Tulane -17.5
College Football Game Picker: Tulane by 15.96
New Mexico St. Vs Tennessee
Vegas: Tennessee -40.5
College Football Game Picker: Tennessee by 39.56
N. Carolina Vs Wake Forest
Vegas: Wake Forest -6.5
College Football Game Picker: Wake Forest by 7.69
Liberty Vs Florida Intl.
Vegas: Liberty -2.5
College Football Game Picker: Liberty by 5.23
Coastal Carolina Vs Ga. Southern
Vegas: Ga. Southern -2.5
College Football Game Picker: Ga. Southern by 2.66
Purdue Vs Washington
Vegas: Washington -16.5
College Football Game Picker: Washington by 20.12
Utah Vs Baylor
This game is a Premium Pick. See Premium Picks for the lock.
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Utah St. Vs UNLV
Vegas: UNLV -5.5
College Football Game Picker: UNLV by 6.33
Florida Vs Ole Miss
Vegas: Ole Miss -15.5
College Football Game Picker: Ole Miss by 16.53
Delaware Vs Sam Houston
Vegas: Delaware -9.5
College Football Game Picker: Delaware by 13.79
Texas Vs Georgia
Vegas: Georgia -5.5
College Football Game Picker: Georgia by 6.62
UCLA Vs Ohio St.
Vegas: Ohio St. -31.5
College Football Game Picker: Ohio St. by 32.75
Virginia Tech Vs Florida St.
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 12
Mississippi St. Vs Missouri
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 12
Kennesaw St. Vs Jacksonville St.
Vegas: Kennesaw St. -3.5
College Football Game Picker: Kennesaw St. by 2.44
La Tech Vs Washington St.
Vegas: Washington St. -7.5
College Football Game Picker: Washington St. by 6.97
TCU Vs BYU
Vegas: BYU -6.5
College Football Game Picker: BYU by 7.71
Boise St. Vs San Diego St.
Vegas: San Diego St. -2.5
College Football Game Picker: Boise St. by 3.71
Wyoming Vs Fresno St.
Vegas: Fresno St. -4.5
College Football Game Picker: Fresno St. by 8.70
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