2025 College Football Week 6 will feature Miami FL Vs Florida St., Texas Vs Florida, and Vanderbilt Vs Alabama.
We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well!
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread.
The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Thursday, October 2nd, 2025:
Sam Houston Vs New Mexico St.
Vegas: Sam Houston -1.5
College Football Game Picker: New Mexico St. by 3.29
Friday, October 3rd, 2025:
Charlotte Vs S. Florida
Vegas: S. Florida -27.5
College Football Game Picker: S. Florida by 33.61
W. Kentucky Vs Delaware
Vegas: Delaware -2.5
College Football Game Picker: W. Kentucky by 3.09
New Mexico Vs San Jose St.
Vegas: San Jose St. -2.5
College Football Game Picker: New Mexico by 7.04
W. Virginia Vs BYU
Vegas: BYU -18.5
College Football Game Picker: BYU by 23.53
Colorado St. Vs San Diego St.
Vegas: San Diego St. -5.5
College Football Game Picker: San Diego St. by 11.90
Saturday, October 4th, 2025:
Air Force Vs Navy
Vegas: Navy -11.5
College Football Game Picker: Navy by 14.24
Kentucky Vs Georgia
Vegas: Georgia -20.5
College Football Game Picker: Georgia by 19.46
Iowa St. Vs Cincinnati
Vegas: Cincinnati -1.5
College Football Game Picker: Iowa St. by 0.20
Wisconsin Vs Michigan
Vegas: Michigan -16.5
College Football Game Picker: Michigan by 20.70
Clemson Vs N. Carolina
This game is a Premium Pick. See Premium Picks for the lock.
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Boston College Vs Pittsburgh
Vegas: Pittsburgh -6.5
College Football Game Picker: Pittsburgh by 4.45
Ohio Vs Ball St.
Vegas: Ohio -14.5
College Football Game Picker: Ohio by 22.56
Illinois Vs Purdue
Vegas: Illinois -9.5
College Football Game Picker: Illinois by 10.64
Kansas St. Vs Baylor
Vegas: Baylor -6.5
College Football Game Picker: Baylor by 6.92
Army Vs UAB
Vegas: Army -6.5
College Football Game Picker: Army by 11.62
Temple Vs UTSA
Vegas: UTSA -6.5
College Football Game Picker: UTSA by 6.41
Wake Forest Vs Virginia Tech
Vegas: Virginia Tech -6.5
College Football Game Picker: Virginia Tech by 4.71
W. Michigan Vs UMass
Vegas: W. Michigan -11.5
College Football Game Picker: W. Michigan by 21.31
Oklahoma St. Vs Arizona
This game is a Premium Pick. See Premium Picks for the lock.
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Oregon St. Vs Appalachian St.
Vegas: Appalachian St. -1.5
College Football Game Picker: Oregon St. by 7.02
Virginia Vs Louisville
Vegas: Louisville -6.5
College Football Game Picker: Louisville by 1.29
Washington Vs Maryland
Vegas: Washington -6.5
College Football Game Picker: Washington by 9.70
C. Michigan Vs Akron
Vegas: C. Michigan -7
College Football Game Picker: C. Michigan by 10.18
E. Michigan Vs Buffalo
Vegas: Buffalo -10
College Football Game Picker: Buffalo by 10.11
James Madison Vs Georgia St.
This game is a Premium Pick. See Premium Picks for the lock.
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La Monroe Vs Northwestern
Vegas: Northwestern -11.0
College Football Game Picker: Northwestern by 13.25
Miami OH Vs N. Illinois
Vegas: Miami OH -3.5
College Football Game Picker: Miami OH by 3.82
Penn St. Vs UCLA
Vegas: Penn St. -24.5
College Football Game Picker: Penn St. by 28.43
Texas Vs Florida
Vegas: Texas -6.5
College Football Game Picker: Texas by 11.29
Vanderbilt Vs Alabama
Vegas: Alabama -10.5
College Football Game Picker: Alabama by 10.59
Syracuse Vs SMU
Vegas: SMU -17.5
College Football Game Picker: SMU by 7.68
Florida Intl. Vs UConn
Vegas: UConn -7.5
College Football Game Picker: UConn by 11.57
Boise St. Vs Notre Dame
Vegas: Notre Dame -20.5
College Football Game Picker: Notre Dame by 19.48
Michigan St. Vs Nebraska
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 6
Kent St. Vs Oklahoma
Vegas: Oklahoma -45.5
College Football Game Picker: Oklahoma by 55.02
Texas St. Vs Arkansas St.
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 6
Coastal Carolina Vs Old Dominion
This game is a Premium Pick. See Premium Picks for the lock.
Click Here for the Premium Picks for Week 6
S. Alabama Vs Troy
Vegas: S. Alabama -1.5
College Football Game Picker: Troy by 2.38
Florida Atl. Vs Rice
Vegas: Rice -4.5
College Football Game Picker: Rice by 8.78
Texas Tech Vs Houston
Vegas: Texas Tech -11.5
College Football Game Picker: Texas Tech by 15.18
UNLV Vs Wyoming
Vegas: UNLV -3.5
College Football Game Picker: UNLV by 8.02
Kansas Vs C. Florida
Vegas: Kansas -4.5
College Football Game Picker: Kansas by 4.43
Minnesota Vs Ohio St.
Vegas: Ohio St. -23.5
College Football Game Picker: Ohio St. by 21.77
Miami FL Vs Florida St.
Vegas: Miami FL -5.5
College Football Game Picker: Miami FL by 0.98
Colorado Vs TCU
Vegas: TCU -14.5
College Football Game Picker: TCU by 12.22
Mississippi St. Vs Texas A&M
Vegas: Texas A&M -14.5
College Football Game Picker: Texas A&M by 12.48
Tulsa Vs Memphis
Vegas: Memphis -20.5
College Football Game Picker: Memphis by 23.93
Duke Vs California
Vegas: Duke -2.5
College Football Game Picker: Duke by 4.97
Nevada Vs Fresno St.
Vegas: Fresno St. -13.5
College Football Game Picker: Fresno St. by 22.50
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