2025 College Football Week 4 features Auburn Vs Oklahoma, Illinois Vs Indiana, and Michigan Vs Nebraska.
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Week 4
Thursday, September 18th, 2025:
Rice Vs Charlotte
Vegas: Rice -2.5
College Football Game Picker: Rice by 11.80
Charlotte has been horrible on offense against FBS schools and has the 133rd easiest schedule. Rice will matchup well against Charlotte with its 32th ranked pass offense going against the 88th ranked pass defense of Charlotte. Charlotte is a pass first team, but will struggle to move the ball against the 13th ranked pass defense of Rice. The 135th ranked Charlotte rush offense won’t be able to take advantage of the poor Rice run defense. Look for Rice to cover the spread in this one.
Saturday, September 20th, 2025:
Ball St. Vs UConn
Vegas: UConn -20.5
College Football Game Picker: UConn by 28.25
Ball St. is horrible and has only scored 3 points versus FBS schools this season. UConn on the other hand has had close losses, but put up lots of points in all three of its games. UConn will have a huge mismatch with its 18th ranked pass offense going against the 126th ranked pass defense of Ball St. UConn’s main weakness has been its 132nd ranked pass defense. Ball St. won’t be able to take advantage of the poor pass defense with its 132nd ranked pass offense. Look for UConn to cover the spread at home in this one.
Saturday, September 20th, 2025:
Coastal Carolina Vs S. Alabama
Vegas: S. Alabama -14.5
College Football Game Picker: S. Alabama by 27.52
Coastal Carolina has been really bad on both sides of the ball this year ranking over 100 in all statistical categories. S. Alabama even with two losses against Tulane and Auburn has played well and put points on the board. The 47th ranked rush offense of S. Alabama will be able to move the ball efficiently against the 103rd ranked rush defense of Coastal Carolina. S. Alabama has played a much tougher schedule and will be able to cover the spread at home against a terrible Coastal Carolina team.
Saturday, September 20th, 2025:
S. Carolina Vs Missouri
Vegas: Missouri -11.5
College Football Game Picker: Missouri by 21.92
Missouri’s offense has been unstoppable in the first three games of the season ranking 1st in rush offense and 39th in pass offense. S. Carolina has been unable to get a running game going and was boat raced at home by Vanderbilt this past weekend after their starting QB went out with a head injury. Missouri has been impressive on defense ranking 13th in rush defense and 7th in pass defense. Look for 19th ranked Missouri to cover the spread against 42nd ranked S. Carolina.
Saturday, September 20th, 2025:
La Monroe Vs UTEP
Vegas: UTEP -4.5
College Football Game Picker: UTEP by 20.55
UTEP played well against SEC powerhouse Texas only losing 27-10. La Monroe lost 73-0 against Alabama in its last outing and had a bye this past weekend. UTEP has been undervalued by Vegas with a +11 against the spread average. The 87th ranked pass offense of UTEP will be able to put up points on the 135th ranked pass defense of La Monroe. The UTEP defense showed it is more than capable after holding Texas to 27 points. Look for UTEP to cover the spread in this one at home.
Saturday, September 20th, 2025:
California Vs San Diego St.
Vegas: California -12.5
College Football Game Picker: California by 24.29
California has found a QB and has been piling up yards through the air. San Diego St. has been unable to move the ball through the air or on the ground with its 120th ranked rush offense and 124th ranked pass offense against the worst ranked schedule in the country. California will have a big mismatch with its 39th ranked pass offense going against the 98th ranked pass defense of San Diego St. Look for the surprising 50th ranked California Bears to cover the spread against 115th ranked San Diego St.
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