2025 College Football Week 2 ( September 5th – September 6th) will feature Michigan Vs Oklahoma, Iowa Vs Iowa St, and Kansas Vs Missouri.
We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well!
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread.
The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Friday, September 5th, 2025:
James Madison Vs Louisville
Vegas: Louisville -14.5
College Football Game Picker: Louisville by 16.97
N. Illinois Vs Maryland
Vegas: Maryland -16.5
College Football Game Picker: Maryland by 16.96
Saturday, September 6th, 2025:
Florida Intl. Vs Penn St.
Vegas: Penn St. -41.5
College Football Game Picker: Penn St. by 50.75
Kent St. Vs Texas Tech
Vegas: Texas Tech -48.5
College Football Game Picker: Texas Tech by 50.77
Virginia Vs NC State
This game is a Premium Pick. See Premium Picks for the lock.
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San Jose St. Vs Texas
Vegas: Texas -36.5
College Football Game Picker: Texas by 46.90
Liberty Vs Jacksonville St.
Vegas: Liberty -6.5
College Football Game Picker: Liberty by 11.55
C. Michigan Vs Pittsburgh
Vegas: Pittsburgh -21.5
College Football Game Picker: Pittsburgh by 30.18
Iowa Vs Iowa St.
Vegas: Iowa St -3.5
College Football Game Picker: Iowa by 0.78
UConn Vs Syracuse
Vegas: Syracuse -7.5
College Football Game Picker: Syracuse by 1.28
Baylor Vs SMU
Vegas: SMU -2.5
College Football Game Picker: Baylor by 7.03
Illinois Vs Duke
Vegas: Illinois -2.5
College Football Game Picker: Illinois by 8.45
Kennesaw St. Vs Indiana
Vegas: Indiana -35.5
College Football Game Picker: Indiana by 41.39
Utah St. Vs Texas AM
Vegas: Texas AM -28.5
College Football Game Picker: Texas AM by 45.07
Ole Miss Vs Kentucky
This game is a Premium Pick. See Premium Picks for the lock.
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Kansas Vs Missouri
Vegas: Missouri -6.5
College Football Game Picker: Missouri by 13.25
UAB Vs Navy
Vegas: Navy -20.5
College Football Game Picker: Navy by 30.44
N. Texas Vs W. Michigan
Vegas: N. Texas -9.5
College Football Game Picker: N. Texas by 11.11
Fresno St. Vs Oregon St.
Vegas: Oregon St. -2.5
College Football Game Picker: Oregon St. by 6.89
Troy Vs Clemson
Vegas: Clemson -31.5
College Football Game Picker: Clemson by 45.48
Miami OH Vs Rutgers
Vegas: Rutgers -14.5
College Football Game Picker: Rutgers by 19.39
Bowling Green Vs Cincinnati
Vegas: Cincinnati -17.5
College Football Game Picker: Cincinnati by 28.15
Oklahoma St. Vs Oregon
Vegas: Oregon -28.5
College Football Game Picker: Oregon by 35.23
Texas St. Vs UTSA
This game is a Premium Pick. See Premium Picks for the lock.
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Delaware Vs Colorado
Vegas: Colorado -23.5
College Football Game Picker: Colorado by 26.07
Middle Tenn. Vs Wisconsin
Vegas: Wisconsin -27.5
College Football Game Picker: Wisconsin by 38.20
W. Virginia Vs Ohio
Vegas: W. Virginia -2.5
College Football Game Picker: W. Virginia by 8.82
S. Florida Vs Florida
Vegas: Florida -17.5
College Football Game Picker: Florida by 26.78
Arkansas St. Vs Arkansas
Vegas: Arkansas -22.5
College Football Game Picker: Arkansas by 32.18
Missouri St. Vs Marshall
Vegas: Marshall -8.5
College Football Game Picker: Marshall by 6.82
N. Carolina Vs Charlotte
Vegas: N. Carolina -13.5
College Football Game Picker: N. Carolina by 25.21
Army Vs Kansas St.
This game is a Premium Pick. See Premium Picks for the lock.
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Memphis Vs Georgia St.
This game is a Premium Pick. See Premium Picks for the lock.
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Tulane Vs S. Alabama
Vegas: Tulane -10.5
College Football Game Picker: Tulane by 17.85
W. Kentucky Vs Toledo
Vegas: Toledo -5.5
College Football Game Picker: Toledo by 7.52
Houston Vs Rice
Vegas: Houston -13.5
College Football Game Picker: Houston by 22.26
Vanderbilt Vs Virginia Tech
Vegas: Virginia Tech -2.5
College Football Game Picker: Virginia Tech by 1.9
La Tech Vs LSU
Vegas: LSU -37.5
College Football Game Picker: LSU by 45.88
Boston College Vs Michigan St.
Vegas: Michigan St. -3.5
College Football Game Picker: Michigan St. by 1.39
Ball St. Vs Auburn
Vegas: Auburn -43.5
College Football Game Picker: Auburn by 51.87
Akron Vs Nebraska
Vegas: Nebraska -34.5
College Football Game Picker: Nebraska by 43.67
Arizona St. Vs Mississippi St.
This game is a Premium Pick. See Premium Picks for the lock.
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Michigan Vs Oklahoma
Vegas: Oklahoma -5.5
College Football Game Picker: Oklahoma by 2.66
GA Southern Vs USC
Vegas: USC -27.5
College Football Game Picker: USC by 39.45
La Monroe Vs Alabama
Vegas: Alabama -35.5
College Football Game Picker: Alabama by 44.02
UCLA Vs UNLV
Vegas: UCLA -1.5
College Football Game Picker: UCLA by 11.82
Tulsa Vs New Mexico St.
Vegas: Tulsa -3.5
College Football Game Picker: New Mexico St. by 1.63
Stanford Vs BYU
Vegas: BYU -18.5
College Football Game Picker: BYU by 25.04
San Diego St. Vs Washington St.
Vegas: Washington St. -2.5
College Football Game Picker: San Diego St. by 2.61
Sam Houston Vs Hawaii
Vegas: Hawaii -6.5
College Football Game Picker: Hawaii by 10.98
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