The 2025 College Football season kicks off August 23rd featuring Iowa St. vs Kansas St. in Dublin, Ireland. Enjoy the free college football picks against the spread for the opening weekend! The Premium Picks Against the Spread will start Thursday August 28th, as this is a very slim first weekend.
Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread. The team highlighted in green is the College Football Game Picker team predicted to cover the spread.
Saturday, August 23rd – Iowa St. Vs Kansas St
Vegas Kansas St. -3.5 College Football Game Picker Kansas St. by 3.21
Fresno St. Vs Kansas
Vegas Kansas -13.5 College Football Game Picker Kansas by 18.48
Sam Houston Vs W. Kentucky
Vegas W. Kentucky -10 College Football Game Picker W. Kentucky by 6.00
Stanford Vs Hawaii
Vegas Hawaii -1.5 College Football Game Picker Hawaii by 3.85


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