2021 College Football Week 6 Free Picks and Predictions Against the Spread

The 2021 College Football Week 6 will be featuring Iowa Vs Penn St., Oklahoma Vs Texas, and Auburn Vs Georgia. We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well! 

Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as Covid-19, injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread. The team highlighted in green is the College Football Game Picker team predicted to cover the spread.


Thursday, October 7th  – Houston Vs Tulane

Vegas  Houston -6.5    College Football Game Picker  Houston by 12.58


Coastal Carolina Vs Arkansas St.

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6

Premium Pick Winner from Thursday Night

Coastal Carolina Vs Arkansas St.     Final Score:  Coastal Carolina 52   Arkansas St. 20

Vegas  Coastal Carolina -19    College Football Game Picker  Coastal Carolina by 33.16

Arkansas St. has one of the worst defenses in the country ranking 130th in rush defense and 121st in pass defense. Coastal Carolina will have a huge mismatch with its 8th ranked rush offense and 47th ranked pass offense going against the terrible Arkansas St. defense. The lone bright spot for Arkansas St. this year has been its 3rd ranked pass offense. Coastal Carolina will be able to slow down the Arkansas St. passing game with its 12th ranked pass defense.  Look for Coastal Carolina to cover the spread in this one.


Friday, October 8th  – Temple Vs Cincinnati 

Vegas  Cincinnati -29.5    College Football Game Picker  Cincinnati by 37.35


Charlotte Vs Florida Intl.

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6

Premium Pick Winner from Friday Night

Charlotte Vs Florida Intl.  Final Score:  Charlotte 45   Florida Intl. 33

Vegas  Charlotte -3.5    College Football Game Picker  Charlotte by 10.69

Florida Intl. is another horrible defense ranking 126th in pass defense and 106th in run defense. Charlotte should be able to move the ball effectively with its 45th ranked pass offense and 69th ranked rush offense. Charlotte will be able to slow down the pass first offense (25th) of Florida Intl. with its 47th ranked pass defense. Look for Charlotte to cover the spread in this one.


Stanford Vs Arizona St. 

Vegas  Arizona St. -13.5    College Football Game Picker  Arizona St. by 7.29


Saturday, October 9th  – Michigan St. Vs Rutgers 

Vegas  Michigan St. -5    College Football Game Picker  Michigan St. by 4.48


Maryland Vs Ohio St. 

Vegas  Ohio St. -21.5    College Football Game Picker  Ohio St. by 20.2


Akron Vs Bowling Green 

Vegas  Bowling Green -13.5    College Football Game Picker  Bowling Green by 17.25


N. Illinois Vs Toledo 

Vegas  Toledo -12.5    College Football Game Picker  Toledo  by 16.55


S. Carolina Vs Tennessee

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6


W. Virginia Vs Baylor 

Vegas  Baylor -2.5    College Football Game Picker  W. Virginia by 2.31


Vanderbilt Vs Florida

Vegas  Florida -39    College Football Game Picker  Florida by 47.46


Oklahoma Vs Texas

Vegas  Oklahoma -3.5    College Football Game Picker  Texas by 2.80


Arkansas Vs Ole Miss

Vegas  Ole Miss -5.5    College Football Game Picker  Ole Miss by 3.83


Georgia Tech Vs Duke

Vegas  Georgia Tech -4.5    College Football Game Picker  Georgia Tech by 12.06


Old Dominion Vs Marshall 

Vegas  Marshall -21    College Football Game Picker  Marshall by 16.0


Wisconsin Vs Illinois

Vegas  Wisconsin -10.5    College Football Game Picker  Wisconsin by 12.16


Virginia Vs Louisville

Vegas  Louisville -2.5    College Football Game Picker  Louisville by 1.52


Florida St. Vs N. Carolina

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6


UConn Vs UMass

Vegas  UConn -3    College Football Game Picker  UMass by 1.54


Wake Forest Vs Syracuse

Vegas  Wake Forest -5.5    College Football Game Picker  Wake Forest by 8.53


Middle Tenn. Vs Liberty 

Vegas  Liberty -19.5    College Football Game Picker  Liberty by 25.16


Boise St. Vs BYU

Vegas  BYU -6    College Football Game Picker  Boise St. by 0.07


San Jose St. Vs Colorado St.

Vegas  Colorado St. -2.5    College Football Game Picker  Colorado St. by 4.43


SMU Vs Navy

Vegas  SMU -13.5    College Football Game Picker  SMU by 13.69


Georgia Vs Auburn

Vegas  Georgia -15    College Football Game Picker  Georgia by 16.18


Florida Atl. Vs UAB

Vegas  UAB -4    College Football Game Picker  Florida Atl.  by 0.01


Miami OH Vs E. Michigan

Vegas  Miami OH -1.5    College Football Game Picker  Miami OH by 2.17


C. Michigan Vs Ohio

Vegas  C. Michigan -5    College Football Game Picker  C. Michigan by 10.64


Ball St. Vs W. Michigan

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6


N. Texas Vs Missouri

Vegas  Missouri -19    College Football Game Picker  Missouri by 14.23


Penn St. Vs Iowa

Vegas  Iowa -1.5    College Football Game Picker  Iowa by 5.92


Oregon St. Vs Washington St.

Vegas  Oregon St. -3.5    College Football Game Picker  Oregon St. by 12.57


E. Carolina  Vs C. Florida 

Vegas  C. Florida -10    College Football Game Picker  C. Florida by 9.88


Michigan Vs Nebraska

Vegas  Michigan -2.5    College Football Game Picker  Michigan by 6.85


Buffalo Vs Kent St.

Vegas  Kent St. -6.5    College Football Game Picker  Buffalo by 1.4


Wyoming Vs Air Force

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 6


TCU Vs Texas Tech

Vegas  TCU -2.5    College Football Game Picker  TCU by 0.57


S. Alabama Vs Texas St.

Vegas  S. Alabama -3.5    College Football Game Picker  S. Alabama by 12.08


Ga. Southern Vs Troy

Vegas  Troy -5.5    College Football Game Picker  Troy by 13.08


UTEP Vs Southern Miss

Vegas  UTEP -2.5    College Football Game Picker  UTEP by 0.95


UTSA Vs W. Kentucky

Vegas  W. Kentucky -3    College Football Game Picker  UTSA by 5.02


LSU Vs Kentucky

Vegas  Kentucky -2.5    College Football Game Picker  LSU by 0.10


Notre Dame Vs Virginia Tech

Vegas  PK    College Football Game Picker  Notre Dame by 11.08


Utah Vs USC

Vegas  USC -3    College Football Game Picker  USC by 10.21


Georgia St. Vs La. Monroe

Vegas  Georgia St. -16   College Football Game Picker  Georgia St. by 11.38


Alabama Vs Texas A&M

Vegas  Alabama -18.5    College Football Game Picker  Alabama by 16.59


Memphis Vs Tulsa

Vegas  Tulsa -3.5    College Football Game Picker  Memphis by 2.23


New Mexico Vs San Diego St.

Vegas  San Diego St. -19.5    College Football Game Picker  San Diego St. by 24.1


UCLA Vs Arizona

Vegas  UCLA -16    College Football Game Picker  UCLA by 22.23


New Mexico St. Vs Nevada

Vegas  Nevada -28.5    College Football Game Picker  Nevada by 27.02


Vegas Odds for Week 6

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