{"id":29850,"date":"2025-09-29T07:01:50","date_gmt":"2025-09-29T13:01:50","guid":{"rendered":"https:\/\/collegefootballgamepicker.com\/Picker\/?p=29850"},"modified":"2025-10-06T05:32:04","modified_gmt":"2025-10-06T11:32:04","slug":"2025-college-football-week-6-premium-picks-against-the-spread","status":"publish","type":"post","link":"https:\/\/collegefootballgamepicker.com\/Picker\/2025-college-football-week-6-premium-picks-against-the-spread\/","title":{"rendered":"2025 College Football Week 6 Premium Picks Against the Spread"},"content":{"rendered":"

2025 College Football Week 6 will feature Miami FL Vs Florida St., Texas Vs Florida, and Vanderbilt Vs Alabama.<\/strong><\/p>\n

We will have 6 Premium Picks against the spread this week! <\/strong><\/p>\n

Enjoy the free college football picks against the spread as well!\u00a0<\/strong><\/p>\n

Premium Picks are made public once the games are played.<\/p>\n

Week 6<\/strong><\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

Clemson<\/span> Vs N. Carolina<\/strong><\/span><\/p>\n

Vegas:<\/span> Clemson<\/strong><\/span>\u00a0<\/strong><\/span>-13.5<\/strong><\/p>\n

College Football Game Picker:<\/span> Clemson <\/strong><\/span>by 17.33<\/strong><\/p>\n

\"\"<\/a><\/p>\n

Clemson was preseason Top 5 in pretty much everyone’s rankings. Clemson has stumbled out of the blocks but had a weekend off to fix things. N. Carolina has been absolutely terrible on offense ranking 126th in rushing offense and 118th in pass offense. Clemson has a very talented defense that will be able to shut down N. Carolina. The underperforming offense of Clemson should finally be able to get well in this game with its 42nd ranked pass offense going against the 94th ranked pass defense of N. Carolina. Look for Clemson to cover the spread in this one.<\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

Oklahoma St. Vs Arizona<\/span><\/strong><\/span><\/p>\n

Vegas:<\/span> Arizona <\/strong><\/span>-19.5<\/strong><\/p>\n

College Football Game Picker:<\/span> Arizona <\/strong><\/span>by 27.94<\/strong><\/p>\n

\"\"<\/a><\/p>\n

Oklahoma St. has been unable to stop anyone on defense ranking 131 in rush defense and 127th in pass defense. Arizona should be able to expose the weak defense of Oklahoma St. with its 41st ranked rushing offense. Meanwhile on defense, Arizona has been solid ranking 18th in rush defense and 44th in pass defense. Oklahoma St. will struggle to get things going with its run first offense. Look for 50th ranked Arizona to cover the spread at home in this one against 111th ranked Oklahoma St.<\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

James Madison<\/span> Vs Georgia St.<\/strong><\/span><\/p>\n

Vegas:<\/span> James Madison<\/strong><\/span>\u00a0<\/strong><\/span>-19.5<\/strong><\/p>\n

College Football Game Picker:<\/span> James Madison<\/strong><\/span>\u00a0<\/strong><\/span>by 33.50<\/strong><\/p>\n

\"\"<\/a><\/p>\n

James Madison will match up well against Georgia St. Georgia St’s pass first offense will struggle against the 4th ranked pass defense of James Madison. On the other side of the ball, James Madison will have a major mismatch with its 13th ranked rushing offense going against the 132nd ranked rush defense of Georgia St. James Madison has been way undervalued by Vegas with a +8 against the spread average for the year. Look for 57th ranked James Madison to cover the spread against 129th ranked Georgia St.<\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

Michigan St. Vs Nebraska<\/span><\/strong><\/span><\/p>\n

Vegas:<\/span> Nebraska <\/strong><\/span>-10.5<\/strong><\/p>\n

College Football Game Picker:<\/span> Nebraska <\/strong><\/span>by 20.70<\/strong><\/p>\n

\"\"<\/a><\/p>\n

This is another game where the strengths and weaknesses of Nebraska match up really well against Michigan St. The 3rd ranked pass offense of Nebraska should have a field day on the 116th ranked pass defense of Michigan St. Michigan St. will struggle to pass the ball against the 1st ranked pass defense of Nebraska. Nebraska will be able to stack the box to slow down the Michigan St. rushing offense. Nebraska has been undervalued by Vegas with a +8 against the spread average. Look for Nebraska to cover the spread in this one.<\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

Texas St.<\/span> Vs Arkansas St.<\/strong><\/span><\/p>\n

Vegas:<\/span> Texas St. <\/strong><\/span>-12.5<\/strong><\/p>\n

College Football Game Picker:<\/span> Texas St. <\/strong><\/span>by 19.59<\/strong><\/p>\n

\"\"<\/a><\/p>\n

If you look at the strength of schedule for these two teams, Arkansas St. is ranked 111th and Texas St. is ranked 83rd. However, Texas St. leads Arkansas St. in every statistical category even though it has played a tougher schedule. Texas St. should be able to run the ball at will with its 17th ranked rushing offense going against the 127th ranked rush defense of Arkansas St. Arkansas St. won’t be able to expose the 122nd ranked rush defense of Texas St. with its 106th ranked rush offense. Look for 73rd ranked Texas St. to cover the spread in this one against 122nd ranked Arkansas St.<\/p>\n

\n

Saturday, October 4th, 2025:<\/span><\/span><\/strong><\/p>\n

Coastal Carolina Vs Old Dominion<\/span><\/strong><\/span><\/p>\n

Vegas:<\/span> Old Dominion <\/strong><\/span>-18.5<\/strong><\/p>\n

College Football Game Picker:<\/span> Old Dominion <\/strong><\/span>by 30.94<\/strong><\/p>\n

\"\"<\/a><\/p>\n

Old Dominion has been one of the most undervalued teams by Vegas with a whopping +15 against the spread average. Meanwhile Coastal Carolina has a -10 against the spread average. The 15th ranked rush offense of Old Dominion will feast on the 110th ranked rush defense of Coastal Carolina. Coastal Carolina won’t be able to take advantage of the 116th ranked rush defense of Old Dominion with its 101st ranked rush offense. Look for 49th ranked Old Dominion to cover the spread against the 116th ranked Coastal Carolina.<\/p>\n

\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

2025 College Football Week 6 will feature Miami FL Vs Florida St., Texas Vs Florida, and Vanderbilt Vs Alabama. We will have 6 Premium Picks against the spread this week! Enjoy the free college football […]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":29840,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","pmpro_default_level":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[410,74,505,261,687,391,393,408,215,725,383,401,411,723,726,416],"class_list":{"0":"post-29850","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-computer-generated-predictions-used-in-conjunction-with-intangibles-to-give-the-user-a-sampling-of-college-football-game-picks","8":"tag-bleacher-report-college-football","9":"tag-college-football","10":"tag-collegefootballcomputerpicks","11":"tag-college-football-computer-picks-ats","12":"tag-college-football-game-picker-2025","13":"tag-college-football-game-picks-this-week","14":"tag-college-football-handicappers-free-picks","15":"tag-college-picks-against-the-spread","16":"tag-handicapper","17":"tag-miami-fl-vs-florida-st","18":"tag-ncaa-college-football","19":"tag-ncaa-football-computer-predictions","20":"tag-ncaaf-picks","21":"tag-texas-vs-florida","22":"tag-vanderbilt-vs-alabama","23":"tag-week-6-college-football-predictions","24":"pmpro-has-access"},"yoast_head":"\n2025 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