2021 College Football Week 4 Free Picks and Predictions Against the Spread

The 2021 College Football Week 4 will be featuring Texas A&M Vs Arkansas and Notre Dame Vs Wisconsin. We will have 6 Premium Picks against the spread this week! Enjoy the free college football picks against the spread as well! 

Use the Matchup generator below to analyze all games. The Matchup generator exposes potential mismatches showing strong offensive units versus weak defensive units or vice versa. Many other factors are taken into account for the final prediction such as power rankings, returning starters, home field, coaching, strength of schedule, and against the spread average. Finally, intangibles such as Covid-19, injuries, suspensions, weather, and trends will be used in the days leading into the game to provide an accurate prediction for each game versus the Vegas spread. The team highlighted in green is the College Football Game Picker team predicted to cover the spread.


Thursday, September 23rd  – Marshall Vs Appalachian St. 

Vegas  Appalachian St.  -7    College Football Game Picker  Appalachian St. by 9.95


Friday, September 24th  – Middle Tenn. Vs Charlotte

Vegas  Charlotte -3    College Football Game Picker  Middle Tenn. by 3.0


Wake Forest Vs Virginia 

Vegas  Virginia  -4    College Football Game Picker  Virginia by 2.74


Liberty Vs Syracuse 

Vegas  Liberty -6    College Football Game Picker  Liberty by 9.41


UNLV Vs Fresno St.

Vegas  Fresno St. -30    College Football Game Picker  Fresno St. by 37.32


Saturday, September 25th  Bowling Green Vs Minnesota 

Vegas  Minnesota -31    College Football Game Picker  Minnesota by 37.33


Kentucky Vs S. Carolina 

Vegas  Kentucky -5    College Football Game Picker  Kentucky by 1.19


Notre Dame Vs Wisconsin

Vegas  Wisconsin -6    College Football Game Picker  Wisconsin by 11.04


Toledo Vs Ball St. 

Vegas  Toledo -4.5    College Football Game Picker  Toledo by 10.86


San Jose St. Vs W. Michigan 

Vegas  W. Michigan -2.5    College Football Game Picker  W. Michigan by 4.0


Texas St. Vs E. Michigan 

Vegas  E. Michigan -6.5    College Football Game Picker  E. Michigan by 2.93


Kent St. Vs Maryland 

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Illinois Vs Purdue

Vegas  Purdue -11    College Football Game Picker  Purdue by 14.71


UMass Vs Coastal Carolina

Vegas  Coastal Carolina -36    College Football Game Picker  Coastal Carolina by 29.3


Florida Intl. Vs C. Michigan 

Vegas  C. Michigan -11.5    College Football Game Picker  C. Michigan by 15.04


Miami OH Vs Army 

Vegas  Army -7.5    College Football Game Picker  Army by 15.11


Akron Vs Ohio St. 

Vegas  Ohio St. -48.5    College Football Game Picker  Ohio St. by 53.26 


La Lafayette Vs GA Southern 

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Boise St.  Vs Utah St. 

Vegas  Boise St. -9.5    College Football Game Picker  Boise St. by 8.54


Kansas Vs Duke

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Missouri Vs Boston College 

Vegas  Missouri -1.5    College Football Game Picker  Boston College by 5.0


Ohio Vs Northwestern

Vegas  Northwestern -14.5    College Football Game Picker  Northwestern by 17.01


N. Carolina Vs Georgia Tech 

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Colorado St.  Vs Iowa 

Vegas  Iowa  -23    College Football Game Picker  Iowa by 34.39


Indiana Vs W. Kentucky 

Vegas  Indiana  -9    College Football Game Picker  Indiana  by 10.64


Florida Atl. Vs Air Force

Vegas  Air Force -4    College Football Game Picker  Florida Atl. by 7.38


Washington St. Vs Utah 

Vegas  Utah -14.5    College Football Game Picker  Utah by 18.46


Hawaii Vs New Mexico St.

Vegas  Hawaii -17    College Football Game Picker  Hawaii by 12.73


S. Florida Vs BYU 

Vegas  BYU -23    College Football Game Picker  BYU  by 25.43


Colorado Vs Arizona St.

Vegas  Arizona St. -14.5    College Football Game Picker  Arizona St. by 10.87


UCLA Vs Stanford 

Vegas  UCLA  -4.5    College Football Game Picker  UCLA  by 5.59


Oregon St. Vs Southern Cal 

Vegas  Southern Cal -10.5    College Football Game Picker  Southern Cal by 13.15


Louisville Vs Florida St. 

Vegas  Louisville -1.5    College Football Game Picker  Louisville by 10.65


Kansas St. Vs Oklahoma St. 

Vegas  Oklahoma St. -6    College Football Game Picker  Kansas St. by 3.22


Southern Miss Vs Alabama

Vegas  Alabama -45.5    College Football Game Picker  Alabama by 40.79


Georgia Vs Vanderbilt

Vegas  Georgia -34.5    College Football Game Picker  Georgia by 48.88


Navy Vs Houston 

Vegas  Houston -18.5    College Football Game Picker  Houston by 24.29


W. Virginia Vs Oklahoma

Vegas  Oklahoma -17    College Football Game Picker  Oklahoma by 11.35


LSU Vs Mississippi St.

Vegas  LSU  -2.5    College Football Game Picker  LSU  by 2.77


Wyoming Vs UConn

Vegas  Wyoming -30.5    College Football Game Picker  Wyoming by 28.49


UAB Vs Tulane

Vegas  Tulane -3.5    College Football Game Picker  Tulane by 2.32


Texas Tech Vs Texas

Vegas  Texas -8    College Football Game Picker  Texas by 14.66


UTSA Vs Memphis 

Vegas  Memphis -3.5    College Football Game Picker  UTSA by 0.79


SMU Vs TCU

Vegas  TCU -9.5    College Football Game Picker  TCU by 8.66


Iowa St. Vs Baylor 

Vegas  Iowa St. -7    College Football Game Picker  Iowa St. by 0.80


Tennessee Vs Florida

Vegas  Florida -19    College Football Game Picker  Florida by 17.63


Clemson Vs NC State 

Vegas  Clemson  -10    College Football Game Picker  Clemson  by 4.21


Nebraska Vs Michigan St. 

Vegas  Michigan St. -5    College Football Game Picker  Michigan St. by 0.28


Rutgers Vs Michigan 

Vegas  Michigan -20    College Football Game Picker  Michigan by 20.74


Texas A&M Vs Arkansas

Vegas  Texas A&M -5.5    College Football Game Picker  Arkansas by 2.81


Troy Vs La Monroe

Vegas  Troy -23.5    College Football Game Picker  Troy by 25.88


Georgia St. Vs Auburn

Vegas  Auburn -27    College Football Game Picker  Auburn by 38.11


Arkansas St. Vs Tulsa

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Buffalo Vs Old Dominion

Vegas  Buffalo  -13    College Football Game Picker  Buffalo by 13.19


N. Texas Vs La Tech

Vegas  La Tech -11    College Football Game Picker  La Tech by 11.42


New Mexico Vs UTEP 

Vegas  New Mexico -1    College Football Game Picker  UTEP by 3.57


California Vs Washington 

This game is a Premium Pick. 

See Premium Picks for the lock. Click Here for the Premium Picks for Week 4


Arizona Vs Oregon

Vegas  Oregon -28.5    College Football Game Picker  Oregon by 36.16


Vegas Odds for Week 4

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